My problem that i have 7-10 server connected to one database (for read permission), all server connected to the remote server. Can implement some cache or something else to fixed it.
Stall report (by sampler 1.58): http://pastebin.com/95RcdcRA

Unfortunately PermissionsEx is currently unmaintained and no further updates are planned. Because of this, all pull requests are being closed. If you are looking for an actively maintained permissions plugin, take a look at LuckPerms. It is compatible with major server platforms and can import data from PEX.