Hey,

I wish, i could start a Draconic Evolution Mobspawner with Applied Energistics.
But if I try to use 2 Mobsouls as Input and 1 as output, it is always simulating.

As example: https://dl.dropboxusercontent.com/u/36365753/AE%20Draconic.jpg

Is it possible to do this?

No, this is not possible because you are effectively using the same item as input and output which means that the recipe is recursive.