The night-vision goggles from the Artifacts mod cause a memory leak while equipped with a maxed Alchemist perks tree - some 200-500MB getting stuck in old-gen G1GC per run. This might affect all items that grant a refreshing potion buff - the specifics of why that one item is causing it aren't entirely clear to me.

This is a know issue. Same issue occurs with the Traveler's Backpack mod. It has something to do with potions effects being applied and getting removed every single tick, but I'm not sure which this is causing a memory leak. I'll have to look into this further.

@CliffracerX Do you know which of the Alchemist power-ups is causing this memory leak specifically?