As of Bedrock Ores MC1.19.2-2.0.0+59a42bf and Create 0.5.1b, Bedrock Ores cannot be broken by Create's andesite drills, either on contraptions or as blocks. This isn't a super huge issue since there's already a machine to mine Bedrock Ores for you and there's plenty of Create->RF mods (plus, Create can be used to automate a lot of fuel production), but it'd be nice to be able to make contraptions that mine bedrock ores.

So I looked into this, because I too am interested in combining these to mods.

The issue would require create and bedrock ores to add a method of compatibility. Simplest would be a create:can_be_mined tag, that bedrock ores then adds to the block tags. However, I am not sure this would solve the main issue, since you would need a custom implementation of the drill to be able to mine bedrock_ores below bedrock(unless you are okay with just the top layer.)

You want a way to mine these with create. My ideal implementation of something like that would be fracking.
Using pipes you pump water into bedrock.
Then reverse and you extract bedrock slurry.
Heat and mix this to filter out the sediments and random ores, leaving you with just water.

IF you do the same process in an area with bedrockores:bedrock_ore you instead get (ore_name_here)_bedrock_slurry, which has a higher return rate on that specific ore(idk 1.25*blockdrop?)

This solves the issue of not being able to reach all the bedrock ores, and adds a layer of complexity to the process instead of just mine block.

That or a giant multiblock drill that gets lowered into the bedrock and mines a 5x5x5 area or something.

I like the idea of a fracking mechanic, but it sounds like it'd require a lot of extra work on the dev's part. (It's also a teensy bit disappointing, because I was so very proud of the reciprocating Factorio-style drill that I'd made...)

The simplest way to implement it, frankly, would be to have the Bedrock Ore Miner take water as an input fluid. IIRC it can already take liquid fuels, so it'd just be a matter of configuring water as a 'fuel'.