Do I have to go through all 445 .bc files? (please say no, please say no, please say no) lol

I'm creating a R.A.D. + SkyFactory modpack. So I would like there to be no coal/iron/diamond/ect ect

Yes you do have to change every biome config, but you can use a text editor like notepad++ to find and replace the whole folder at once.

If you replace
Ore(IRON_ORE,9,20,100.0,0,63,STONE:0)

With
#Ore(IRON_ORE,9,20,100.0,0,63,STONE:0)

in all files in the WorldBiomes folder it will comment out the line and make it no longer function.