Minecraft 1.16.4
Forge: 35.1.37
Create: 1.16.3_v0.3e
Curios: 4.0.3.5

I am assembling a modpack and found that after being in the world for some time, the memory use starts inching up. This eventually starts to cause the game to lag and pause every so often. After disabling and enabling the over 150 mods I found that Create is the mod that seems to be influencing this behavior. I don't have much more to help this to be found and fixed but if I can offer more info, please let me know as I would love to resolve this.

Update:
Updated several mods with multiple fixes and I'm speculating that the updates for interactions have fixed the issue. Went 2.5 hours this last time with a LAN connection and didn't have any issues. I'm closing this issue for now but if it returns or I have more info I'll update and/or re-open it if needed.