I feel like destroy could use some debuffs that are more fun than just reskinned withering for when the chemistry system is all figured out.

Madness:
Makes it so that you'll randomly hear hostile mob noises behind you and punch neutral mobs in front of you. Effect of neurotoxic chemicals. Can be reversed be eating enough fish or maybe lithium carbonate.

Muscle Weakness:
Makes it so that you'll randomly drop the item you are holding. Can be reversed by eating eggs or taking creatine.

Outlaw:
Makes it so that iron golems in villages will be aggressive towards you by default. Take a guess what substance would cause this. Can be reversed by taking said substance out of your inventory.

Bonus debuff:

When you split an item stack while in your inventory your character will do the math wrong and the stack won't split right. (I feel like this one would hard to implement though)