I'm sure #121 is having the same problem I'm getting. I tested with lots of sets of mods, and I finally noticed that Epic Fights Mod is the reason.
Scaling Health mod changes player's base health/attack damage, and Epic Fights mod changes the dodge speed/attack cooldown depending on them.
So, making progress in Scaling Health mod means slower dodges and attack, and it gets slower, and slower... until the attack speed gets close to zero, or even negative, and eventually it is impossible to melee attack, and the world becomes pretty much unplayable. You can't even punch with bare hands.
It will be less serious if the vanilla attacking mode(or mining mode) was not effected, but sadly it does.

I suggest two ideas to fix it: 1) Set a config to disable this "dodge/attack speed scaling" feature. 2) Set the lower speed limit(75% of the original attack speed and 50% of the original dodge speed or something like that). Or, set a new config for the user to set the limit themselves. Or, you know, implement all of them.
I mean, you could remove the feature completely, but I actually like this idea of slower, heavier attack thingy, so I'll be sad to see it go. But the game should be playable, and this certainly needs to be fixed.

Finally, this mod is a legend! Thank you and keep up the great work!