With big mod packs like Moderk Skyblock 3 restarting minecraft takes several minutes.
So it would be a lot better if there would be a command to move the information to a different position on the fly.

You can already reload the config file on the fly, by using /igi reload.

I do not want to reload the config file but change the x and y coordinates of an information block. For example the topleft should now be at x = 2 and y = 150.

Open the mod list, select the mod and click on the config button.

I also figured this out but guessing pixels is hard so you might have to open and close a bunch of menus several times until you got the correct position. With a command this would be way easier.