Having an intermittent issue with Lootr. There seems to be no rhyme or reason to it. World wide, regardless of dimension / when it was loaded, some chest will open with no issue, while the majority will simply do nothing when I interact. No errors server side, no errors client side, no crashing. Chest just can't be interacted with (looted, broken, blown up, etc.) I've scoured the issues page for known conflicts, and am leaning towards Terralith, TerraBlender, or Loot Integrations for likely culprits, but thought maybe if there was a way to "reload" all the chests? Not immediately jumping out at me in terms of how to accomplish, but figured it couldn't hurt to ask.

NeoForge v21.5.51
Lootr v1.21-1.10.33.82

Modlist:

Tool Belt (by gigaherz)
Not Enough Recipe Book [NERB] (by SSKirillSS)
Applied Energistics 2 (by thetechnici4n)
Integrated Dynamics (by kroeser)
OpenBlocks Trophies (by GizmoTheMoonPig)
Torchmaster (by xalcon)
Monster Plus (by Nitespring)
AE2 QoL Recipes (by Christofmeg)
FTB Ultimine (Forge) (by FTB)
Flower Patch (by Mrbysco)
Chunky (Forge/NeoForge) (by pop4959)
Macaw's Paths and Pavings (by sketch_macaw)
Controlling (by Jaredlll08)
Nyf's Spiders (by Nyfaria)
Bank Storage (by Natte)
Explorify – Dungeons & Structures (by bebebea_loste)
When Dungeons Arise - Seven Seas (by Aureljz)
Building Gadgets (by Direwolf20)
Inventory HUD+ (by dmitrylovin)
Konkrete [Forge/NeoForge] (by Keksuccino)
Skin Layers 3D (Fabric/Forge) (by tr7zw)
Resourceful Lib (by ThatGravyBoat)
MC style paintings (by SP_Studios)
Tree Harvester (by Serilum)
Crying Portals (by Serilum)
Durability Tooltip (by SuperMartijn642)
PolyLib (by Official_CreeperHost)
Sky Villages [Forge] (by y4z0n)
Additional Lanterns (by SuperMartijn642)
SmartBrainLib (Forge/Fabric/Quilt) (by Scimiguy)
Sodium (by JellySquid)
Trims on Tools (by Zeith)
Formations Nether (by SuperMartijn642)
Better Babies (by DatapackGen)
Multipart Machines: Grinding (by Grabolit)
Snow Under Trees (by bl4ckscor3)
AE2 Network Analyser (by GlodBlock)
SuperMartijn642's Config Lib (by SuperMartijn642)
Too Many Paintings! (by axperty)
Apothic Spawners (by Shadows_of_Fire)
Formations Overworld (by SuperMartijn642)
Moonlight Lib (by MehVahdJukaar)
Dark Mode Everywhere (by Buuz135)
Cristel Lib (by Cristelknight)
Better Title Screen (by Girafi)
Macaw's Bridges (by sketch_macaw)
Sodium/Embeddium Extras (by Txni)
Lunar (by Mrbysco)
Loot Integrations[Forge/Fabric] (by someaddon)
Savage Ender Dragon[Forge/Fabric] (by someaddon)
Towns and Towers (by Biban_Auriu)
Macaw's Windows (by sketch_macaw)
Ars Additions (by Jarva)
Eyes in the Darkness (by gigaherz)
Explorer's Compass (by Chaosyr)
Multipart Machines: Farming (by Grabolit)
Apothic Enchanting (by Shadows_of_Fire)
Knight Quest [Reforged] (by xylonity)
Distorted Discs (by BBoldt)
GlitchCore (by TheAdubbz)
Macaw's Bridges - Biomes O' Plenty (by Samlegamer_)
FTB Quests (Forge) (by FTB)
Nature's Compass (by Chaosyr)
Wavey Capes (by tr7zw)
The Twilight Forest (by Benimatic)
Patchouli (by Vazkii)
Complementary Shaders - Unbound (by EminGT)
CraftPresence (by CDAGaming_)
Applied Mekanistics (by ramidzkh)
Iris Shaders (by coderbot)
Baubley Heart Canisters (by traverse_joe)
MinecraftCapes Mod (by james090500)
Macaw's Holidays (by sketch_macaw)
End Remastered [NeoForge/Fabric] (by jack_bagel)
Statues (by ShyNieke)
Connected Glass (by SuperMartijn642)
Just Another Rotten Flesh to Leather Mod (by alexdaum1)
Tidal Towns (by joshieman)
Mekanism Additions (by bradyaidanc)
CrashExploitFixer (by drexhd)
More Music Discs [Fabric/Forge/NeoForge] (by Mars)
Blur+ (by Motschen)
Framework (by MrCrayfish)
Icarus (by Cammie)
Inventory Tweaks - ReFoxed (by LobsterJonn)
Sodium Shadowy Path Blocks (by Rynnavinx)
TerraBlender (NeoForge) (by TheAdubbz)
Sit (by bl4ckscor3)
Polymorphic Energistics (by ninety)
Iceberg [Neo/Forge] (by Grend_G)
FTB Essentials (Forge & Fabric) (by FTB)
Explosive Enhancement: Reforged (by xylonity)
AE2 Things [Forge] (by thetechnici4n)
Formations (Structure Library) (by SuperMartijn642)
TrimsEffects - New Major Update Available! (by Lupin)
Animal Armor Trims - Horse & Wolf (by Lupin)
Brutal Bosses - Custom Bosses[Forge/Fabric] (by someaddon)
Naturally Charged Creepers (by Serilum)
Rechiseled: Chipped (by the_iwolfking)
UniLib (by CDAGaming_)
Additional Lights (by mgen256)
Utilitarian (by LobsterJonn)
Macaw's Lights and Lamps (by sketch_macaw)
Farming for Blockheads (by BlayTheNinth)
JourneyMap (by techbrew)
Useful Hats (by thecech12)
Additional Bars [NeoForge] (by Gamma1772)
JamLib (by jamalam360)
MrCrayfish's Furniture Mod: Refurbished (by MrCrayfish)
Cycle Paintings (by Serilum)
Collective (by Serilum)
Mekanism (by bradyaidanc)
FTB Filter System (by FTB)
Enderman Overhaul (by joosh_7889)
Storage Drawers (by Texelsaur)
Complementary Shaders - Reimagined (by EminGT)
Relics: Artifacts Compat (by SSKirillSS)
Spooklementary (by SpacEagle17)
SuperMartijn642's Core Lib (by SuperMartijn642)
Mouse Tweaks (by YaLTeR)
Architectury API (Fabric/Forge/NeoForge) (by shedaniel)
Macaw's Fences - Biomes O' Plenty (by Samlegamer_)
Iron's Spells 'n Spellbooks (by Iron431)
Macaw's Doors (by sketch_macaw)
Integrated Terminals (by kroeser)
Puzzles Lib [Forge & Fabric] (by Fuzs)
Rechiseled (by SuperMartijn642)
Biomes O' Plenty (by Forstride)
Mob Plaques (by Fuzs)
Placebo (by Shadows_of_Fire)
Jade 🔍 (by Snownee)
Occultism (by kli_kli)
Cooking for Blockheads (by BlayTheNinth)
ATO - All the Ores (by ATMTeam)
Passive Shield (by Serilum)
Extreme sound muffler - (Neo)Forge (by LeoBeliik)
Jump Over Fences (by Kreezxil)
Powah! (Rearchitected) (by thetechnici4n)
Clean Swing Through Grass (by Raycoms)
HammerLib (by Zeith)
Modonomicon (by kli_kli)
Balm (Forge Edition) (by BlayTheNinth)
Functional Armor Trim (by tfarecnim)
ImmediatelyFast (by RaphiMC)
Comforts (Fabric/Forge/Quilt) (by TheIllusiveC4)
Macaw's Trapdoors (by sketch_macaw)
Sound​s (by IMB11)
AEInfinityBooster (by hexeptiondev)
Noble Shaders (by Belmu)
Macaw's Roofs (by sketch_macaw)
Macaw's Paintings (by sketch_macaw)
Ars Nouveau (by baileyholl2)
FancyMenu (by Keksuccino)
Sodium Leaf Culling (by Txni)
Werewolves - Become a Beast! (by Cheaterpaul)
Just Enough Items (JEI) (by mezz)
Time in a bottle [FORGE\NEOFORGE\FABRIC] (by MangoRage)
AppleSkin (by squeek502)
Animal Feeding Trough [Fabric | Forge | Quilt | NeoForge] (by Slexom)
Glodium (by GlodBlock)
Measurements (by Mrbysco)
GraveStone Mod (by henkelmax)
RedHat Shaders v34.3 (by mlgimposter)
Trash Cans (by SuperMartijn642)
Multipart Machines: Storage (by Grabolit)
Pixel Perfect Shaders (by epcr)
Polymorph (Fabric/Forge/Quilt) (by TheIllusiveC4)
Polytone (by MehVahdJukaar)
Cupboard (by someaddon)
FTB Backups 2 (by FTB)
Creeper Overhaul (by joosh_7889)
Titanium (by Buuz135)
Transmog (by Hidoni)
The Undergarden (by Quek04)
Easy Villagers (by henkelmax)
Sophisticated Storage (by P3pp3rF1y)
AdvancedAE (by pedroksl)
DarkSmithing - Smithing Template Recipes (Armor Trims) (Fabric/Forge/NeoForge) (by GamerPotion)
Mystical Agriculture (by BlakeBr0)
Multipart Machines: Mining (by Grabolit)
Common Capabilities (by kroeser)
Relics (by SSKirillSS)
M.R.U (by IMB11)
Iron Jetpacks (by BlakeBr0)
Resourceful Config (by ThatGravyBoat)
Caelus API (Forge/NeoForge) (by TheIllusiveC4)
Falling Leaves (NeoForge/Forge) (by Cheaterpaul)
Simple Voice Chat (by henkelmax)
Macaw's Furniture (by sketch_macaw)
Security Craft (by Geforce132)
cat_jam (by shmove)
Hyperbox (by Commoble)
Nyf's Quivers (by Nyfaria)
Integrated Tunnels (by kroeser)
JourneyMap Integration (by frankV)
MOTP - RPG leveling system (by NAIZO)
[EMF] Entity Model Features [Fabric & Forge] (by traben_0)
GeckoLib (by Gecko)
Melody (by Keksuccino)
AntiBlocksReChiseled (by manmaed)
Handcrafted (by terrariumearth)
Cloth Config API (Fabric/Forge/NeoForge) (by shedaniel)
Crafting Tweaks (by BlayTheNinth)
Prism [Neo/Forge] (by Grend_G)
Fusion (Connected Textures) (by SuperMartijn642)
Colorful Hearts (by Terrails)
Accessories (by Blodhgarm)
Apothic Attributes (AttributesLib) (by Shadows_of_Fire)
Overloaded Armor Bar (by tfarecnim)
Reese's Sodium Options (by FlashyReese)
Searchables (by Jaredlll08)
Athena (by CodexAdrian)
Mekanism Generators (by bradyaidanc)
Toast Control (by Shadows_of_Fire)
Mekanism Tools (by bradyaidanc)
Sound Physics Remastered (by henkelmax)
Villager Hats Mod (by PinkGoosik)
BSL Shaders - Original (by capttatsu)
Wireless Chargers (by SuperMartijn642)
Multipart Machines: Cooking (by Grabolit)
Aquaculture 2 (by Shadow)
Cull Leaves (by Motschen)
Underground Bunkers (by Aureljz)
Waystones (by BlayTheNinth)
Pipez (by henkelmax)
Waddles (by Girafi)
Pick Up Notifier [Forge & Fabric] (by Fuzs)
Common Network (by Mysticdrew)
KleeSlabs (by BlayTheNinth)
Craftable Horse Armour & Saddle [CHA&S] (by EwyBoy)
Terralith (by Starmute)
Cucumber Library (by BlakeBr0)
Dimensional Paintings (by Mrbysco)
Camera Mod (by henkelmax)
Lootr (Forge & NeoForge) (by Noobanidus)
Structure Compass (by Mrbysco)
AE2 Import Export Card (by Ultramegaaa)
Convenient Curios Container (by LeoBeliik)
Mekanism Turrets & Fences (by SkelMaximus)
Sophisticated Core (by P3pp3rF1y)
MonoLib (by jason13official)
RightClickHarvest (by jamalam360)
Legendary Tooltips [Neo/Forge] (by Grend_G)
Functional Storage (by Buuz135)
True Weaponry (by ignition528)
Macaw's Roofs - Biomes O' Plenty (by Samlegamer_)
Mystical Agradditions (by BlakeBr0)
Solas Shader (by Septonious)
CreativeCore (by CreativeMD)
BetterF3 (by cominixo)
Infinite Trading (by Serilum)
Curios API Continuation (by SSKirillSS)
FramedBlocks (by XFactHD)
DarkSmelting - Smelt Armor, Tools & Weapons (Fabric/Forge/NeoForge) (by GamerPotion)
MidnightLib (by TeamMidnightDust)
AdoraBuild: Structures (by AdoraBuild)
Additional Structures (by XxRexRaptorxX)
Spice of Life Onion (by CreativeMD)
Domum Ornamentum (by OrionOnline)
Macaw's Fences and Walls (by sketch_macaw)
MEGA Cells (by ninety)
Cyclops Core (by kroeser)
Macaw's Furnitures - Biomes O' Plenty (by Samlegamer_)
Sophisticated Backpacks (by P3pp3rF1y)
CTD Core (by TheMasterGeneral)
[ETF] Entity Texture Features - [Fabric & Forge] (by traben_0)
Chat Heads (by dzwdz)
Chipped (by terrariumearth)
Dungeons and Taverns (by Nova_Wostra)
Ars Elemental (by Alexth99)
GroovyModLoader (GML) (by matyrobbrt)
OpenBlocks Elevator (by vsngarcia)
Simply Light (by Flanks255)
Iron Furnaces (by XenoMustache)
OctoLib (by SSKirillSS)
Vampirism - Become a vampire! (by maxanier)
ExtendedAE (by GlodBlock)
Rispwind's Additional Paintings [FABRIC/FORGE/NEOFORGE] (by Rispwind)
Aurelj's Paintings (by Aureljz)
Armor Stand Arms (Fabric/Forge/NeoForge) (by GamerPotion)
Artifacts (by ochotonida)
FTB Chunks (Forge) (by FTB)
FTB Library (Forge) (by FTB)
Double Doors (by Serilum)
Applied Energistics 2 Wireless Terminals (by Mari_023)
Just Zoom (by Keksuccino)
FTB Teams (Forge) (by FTB)
Dis-Enchanting Table (by Lupin)
Modular Routers (by desht_08)
Cosmetic Armor Reworked (by LainMI)
Eating Animation [Neo/Forge] (by matyrobbrt)
Clumps (by Jaredlll08)
AE2 JEI Integration (by Tamaized)

Unfortunately, nothing immediately jumps out at me as being problematic.

My initial suggestion would be to target a Lootr block in creative mode (or with cheats/commands enabled) and use /data get block and use tab-completion to fill in the coordinates of the block you're looking at.

It might be possible that, at some point, world/chunk generation failed and the block entities themselves are invalid.

Another suggestion would be to copy the world seed and create a single-player game with that seed, and visit some of the same locations that you had issues with and see if they persist in the single-player world.

If you're still having problems with this, please file a new issue with the information I requested above.