The Y pos for instruments on the panel is flipped
Earlier [0,0] used to be the bottom left, but now it's top left
And a positive Y value moves the instrument downwards
Observed in v20.5.0 BETA22 and on Potato Vehicle Industries pack

So, this is actually proper behavior. Instrument positon should match the pixel position in texture editors. Those use 0,0 as top left, and then +Y is down and +X is right. So while this is a change and might break a few positions, it's actually proper.