I'd like it to be able to be removed - there's not much to configure there, it may only cause confusion. Why even have it? I thought a config access point in Mod Menu was enough.

It's there since the mod is going to get larger and this makes it easier for me to quickly change stuff.
Plus it makes a lot of sense for it to be on sodium's menu, these are rendering optimizations.

Sodium's menu also currently does it better then modmenu. When disabling custom item frame culling it will disable the buttons that require the custom item frame culling to work. The mod menu version only has a tooltip to tell you this.

I might add an option for it later

Will be in the next release. Should be v0.6.0
e09c3ca