Here's the stack-trace:

java.lang.NoClassDefFoundError: net/fabricmc/tinyremapper/IMappingProvider
at me.modmuss50.optifabric.mod.OptifabricSetup.run(OptifabricSetup.java:46)
at java.util.ArrayList.forEach(Unknown Source)
at com.chocohead.mm.Plugin.getMixins(Plugin.java:340)
at org.spongepowered.asm.mixin.transformer.PluginHandle.getMixins(PluginHandle.java:128)
at org.spongepowered.asm.mixin.transformer.MixinConfig.postInitialise(MixinConfig.java:796)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.prepareConfigs(MixinProcessor.java:568)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.select(MixinProcessor.java:462)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.checkSelect(MixinProcessor.java:438)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.applyMixins(MixinProcessor.java:290)
at org.spongepowered.asm.mixin.transformer.MixinTransformer.transformClass(MixinTransformer.java:234)
at org.spongepowered.asm.mixin.transformer.MixinTransformer.transformClassBytes(MixinTransformer.java:202)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.getPostMixinClassByteArray(KnotClassDelegate.java:422)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.tryLoadClass(KnotClassDelegate.java:323)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.loadClass(KnotClassDelegate.java:218)
at net.fabricmc.loader.impl.launch.knot.KnotClassLoader.loadClass(KnotClassLoader.java:119)
at java.lang.ClassLoader.loadClass(Unknown Source)
at java.lang.Class.forName0(Native Method)
at java.lang.Class.forName(Unknown Source)
at net.fabricmc.loader.impl.util.DefaultLanguageAdapter.create(DefaultLanguageAdapter.java:50)
at net.fabricmc.loader.impl.entrypoint.EntrypointStorage$NewEntry.getOrCreate(EntrypointStorage.java:117)
at net.fabricmc.loader.impl.entrypoint.EntrypointContainerImpl.getEntrypoint(EntrypointContainerImpl.java:53)
at net.fabricmc.loader.impl.FabricLoaderImpl.invokeEntrypoints(FabricLoaderImpl.java:384)
at net.fabricmc.loader.impl.launch.knot.Knot.init(Knot.java:160)
at net.fabricmc.loader.impl.launch.knot.Knot.launch(Knot.java:68)
at net.fabricmc.loader.impl.launch.knot.KnotClient.main(KnotClient.java:23)
Caused by: java.lang.ClassNotFoundException: net.fabricmc.tinyremapper.IMappingProvider
at java.lang.ClassLoader.findClass(Unknown Source)
at java.lang.ClassLoader.loadClass(Unknown Source)
at java.lang.ClassLoader.loadClass(Unknown Source)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.loadClass(KnotClassDelegate.java:226)
at net.fabricmc.loader.impl.launch.knot.KnotClassLoader.loadClass(KnotClassLoader.java:119)
at java.lang.ClassLoader.loadClass(Unknown Source)
... 25 more

i have this problem, but, im new in this, what i can do?

i have this problem, but, im new in this, what i can do?

I don't know. There's nothing we can do. Try Sodium and then if optifine will work come back

Since you're on 1.16.5, you'll have to get Fabric Loader 0.14.25.