java.lang.NoClassDefFoundError: net/fabricmc/tinyremapper/IMappingProvider
at me.modmuss50.optifabric.mod.OptifabricSetup.run(OptifabricSetup.java:41)
at java.base/java.util.ArrayList.forEach(ArrayList.java:1511)
at com.chocohead.mm.Plugin.getMixins(Plugin.java:340)
at org.spongepowered.asm.mixin.transformer.PluginHandle.getMixins(PluginHandle.java:128)
at org.spongepowered.asm.mixin.transformer.MixinConfig.postInitialise(MixinConfig.java:796)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.prepareConfigs(MixinProcessor.java:568)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.select(MixinProcessor.java:462)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.checkSelect(MixinProcessor.java:438)
at org.spongepowered.asm.mixin.transformer.MixinProcessor.applyMixins(MixinProcessor.java:290)
at org.spongepowered.asm.mixin.transformer.MixinTransformer.transformClass(MixinTransformer.java:234)
at org.spongepowered.asm.mixin.transformer.MixinTransformer.transformClassBytes(MixinTransformer.java:202)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.getPostMixinClassByteArray(KnotClassDelegate.java:422)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.tryLoadClass(KnotClassDelegate.java:323)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.loadClass(KnotClassDelegate.java:218)
at net.fabricmc.loader.impl.launch.knot.KnotClassLoader.loadClass(KnotClassLoader.java:119)
at java.base/java.lang.ClassLoader.loadClass(ClassLoader.java:519)
at java.base/java.lang.Class.forName0(Native Method)
at java.base/java.lang.Class.forName(Class.java:466)
at net.fabricmc.loader.impl.util.DefaultLanguageAdapter.create(DefaultLanguageAdapter.java:50)
at net.fabricmc.loader.impl.entrypoint.EntrypointStorage$NewEntry.getOrCreate(EntrypointStorage.java:117)
at net.fabricmc.loader.impl.entrypoint.EntrypointContainerImpl.getEntrypoint(EntrypointContainerImpl.java:53)
at net.fabricmc.loader.impl.FabricLoaderImpl.invokeEntrypoints(FabricLoaderImpl.java:384)
at net.fabricmc.loader.impl.launch.knot.Knot.init(Knot.java:160)
at net.fabricmc.loader.impl.launch.knot.Knot.launch(Knot.java:68)
at net.fabricmc.loader.impl.launch.knot.KnotClient.main(KnotClient.java:23)
Caused by: java.lang.ClassNotFoundException: net.fabricmc.tinyremapper.IMappingProvider
at java.base/jdk.internal.loader.BuiltinClassLoader.loadClass(BuiltinClassLoader.java:636)
at java.base/java.lang.ClassLoader.loadClass(ClassLoader.java:519)
at net.fabricmc.loader.impl.launch.knot.KnotClassDelegate.loadClass(KnotClassDelegate.java:226)
at net.fabricmc.loader.impl.launch.knot.KnotClassLoader.loadClass(KnotClassLoader.java:119)
at java.base/java.lang.ClassLoader.loadClass(ClassLoader.java:519)
... 25 more

Can you provide any information about what version of minecraft and optifine and optifabric are you useing?
also can you provide the full log?

Use Fabric Loader 0.14.25, also next time please do a search to see if your issue has already been solved. If this solves your issue please close the ticket.