Crash Log: https://gist.github.com/Nonsanity/405f8aab36f3bcd5e67140366cd9d770

I was picking up Botania runes as they were created using an Advanced Item Collector using an Item Filter set to those specific two runes. In an attempt to make the setup not need me to add each new rune to the whitelist, I changed the filter to disable NBT and Metadata and turned on Ore Dictionary matching, still with the initial two runes (water, fire) in the filter. As soon as the Botania Altar finished making a new, third, rune type (air), the game froze.

Restarting the pack (Project Ozone 3, version 3.0.40) and reloading the world resulted in the same immediate freeze again, probably because the collector was again trying to pick up the rune. The crash log linked to above is from this second instance.

Probably the same a issue #405, going by the crash log.