Guys, i'm rendering a 20s timelapse.
If I leave all settings as default the time to render is aboust 30s. (No Anti Alising)
If I only change anti-alising to 2x the time to render increases to 3 minutes.

Is there any optimization I can do to lessen the difference?

Well you're basically rendering at 4x the initial resolution, so you have to expect slowdowns

but 5 to 10 times the render time?

sounds normal to me