I noticed this with Mystical Agriculture in particular, but it would likely activate in other situations. The higher tier essences each gained the full cost of the Infusion Crystal in addition to the cost of the previous tier. As this both makes it harder to replicate items like Mystical Agriculture essences, as well as adds a matter duplication glitch (turning the higher tier essences into matter, using that matter to create lower tier essences, then crafting them back up), I figured it was best to mention it.

Replication Version: 1.21.1-1.1.15

Titanium Version: 1.21-4.0.34

I noticed this in the FTB OceanBlock 2 modpack, but it seems to be a programming issue, not a compatibility one