If a player has the mining fatigue effect active and picks up any weapon with the two-handed I or II trait, the mining fatigue effect is cleared. Even with a command block repeatedly giving the effect, the weapon clears the effect multiple times per second, if not every tick. This was tested without any other mods installed and using the 1.20.1-forge-3.2.1 version. Not sure if this is intended functionality, but I can't find any mention in the mod description or wiki.