TechReborn 2.1.3.164
Minecraft 1.10.2
Forge 12.18.3.2221

After trying TechReborn out in creative, I'm now trying it in survival.
I've used IC2 for the early game and I've built two machines so far, the Industrial Electrolyzer and the Industrial Grinder. Both impose problems automating:

Industrial Electrolyzer: Only one of the inputs can be inserted with hoppers/pipes. For example if I put Bauxite Dust in the main slot, I can't input Empty Cells into the second slot. If I try to insert the Empty Cells first, they go into the main slot. This means this machine is impossible to automate.

Industrial Grinder: Beside the problem that I can't convert any cells into liquids (neither in the Grinder itself nor any other way) (I will open a second ticket for this), I can still use IC2 Mercury or Water Cells. But the slot for extracting the empty cells is not accessible as well with hoppers/pipes which means I have to automate it with liquids instead of cells.

I have not tried other machines yet, but will report here again whenever I find more examples.

I think I found the issue with the Electrolyzer: https://github.com/TechReborn/TechReborn/blob/1.10.2-backport/src/main/java/techreborn/tiles/TileIndustrialElectrolyzer.java#L111 I think this has to be >=2

And the Industrial Grinder: https://github.com/TechReborn/TechReborn/blob/1.10.2-backport/src/main/java/techreborn/tiles/multiblock/TileIndustrialGrinder.java#L153 this seems to be missing slot 6

Sorry if I'm wrong, I'm not that experienced.