Icons and distance for waypoints do not appear while in the Mesas. Icons do appear however when in Llevigar.
Running Wynntills 0.0.4-beta.64 with default-ish* settings on Fabric Loader 0.14.24.
The problem still occurs when turning off Sodium, Indium, and Lithium.
*Only modified a few keybinds.

I believe waypoint icons and distance do not render when they are further than 5000 blocks away, in this case yours is 5100 so it is not rendering

I believe waypoint icons and distance do not render when they are further than 5000 blocks away, in this case yours is 5100 so it is not rendering

Is this due to client-side settings, Wynntills, or just Minecraft in general?

Wynntils, if you look for World Waypoint Distance in the config, you can edit the number