VanillaFix should improve overall performance, provide better crashes and fix few annoyances and bugs.
My friend and I are playtesting it on dev-build. It looks like everything is working properly on both client and server side so far.

I'm fine with adding VanillaFix.

Crashes are not fun, and it can help the AMD GPU folk to have more than 1 FPS.
I've been using it long-term in my runs, and so far I haven't had a single issue with it.