The problem I mean is that the SMAPI Mod templates I use it with, the default target framework is NET Framework 4.5.2
While SMAPI uses net5.0 how can I use the template smoothly in Visual Studio 2022?

Hi! There's no official SMAPI template, and the unofficial one you found is very outdated. You can follow the steps in the mod author guide to create the project directly instead. If anything is unclear, feel free to ask in #making-mods on the Stardew Valley Discord and we'll be happy to answer your questions.