The spells are shown as invalid, however they work. This only for a few days though. I'm not sure, when it occured the first time. As I normaly don't switch speccs.
Whenever I switch specs (eg back from Guardian to Resto), I need to reload the profile, or else the click-casting is not working. So I noticed, that the icons of the spells shown as invalid.

rebind.
it's not a bug.
in r228, some click-casting issues were fixed, and caused this "issue".