The UI scaled too big after the update and unable to change, also my profile has gone after the update

gone? you mean reset?

My Cell profile settings no longer exist, and the Cell's UI has been enlarged to a point it exceeded my screen that I cannot adjust any setting.

and the scale, actually its not a bug.
the scaling behavior has been changed, you need to set scale to a lower value.
in r248 (will release soon)
there's a slash command /cell rescale to update the scale to a recommended value