Something is not entirely right here regarding health loss.

This is before clicking either of the buttons

https://imgur.com/a/EJzSTNG

This is after clicking the buttons, both giving the same result

https://imgur.com/a/mvWhh3k

Using the optimization I actually lose 315 more hp!

I suspect it might be related to having 2x 60 together with the 3x 45.

Ive noticed it a few other times with this particular group of Croman, Meatball, Pelagos, Kleia and Mikanikos.

Edit: I had thought it was soul cinders missions only, but Ive noticed it happening with other missions too with this group.