After using Advanced Optimization with "Optimize Concentration Value" checked, the resulting profit per concentration is lower than I am able to achieve manually. For instance, in the attached screenshot the optimizer suggests using rank 1 vials, but using rank 3 vials instead leads to a higher concentration value.

Possibly due to craftsim going from q1 to q2 to q3 when optimizing and stopping when a "translation" is not viable
so when q1 -> q2 is not viable it does not check q1 -> q3

will take a look if I can improve that

I've been looking at my other crafts, and I have found recipes where q2 reagents result in the most value, but it still suggests q1. As I dug into it a bit, it seems swapping the q1 reagents for q2 one at a time results in a decrease in concentration value, until it reaches a breakpoint and then the value starts increasing rapidly as you add more q2 reagents.

In the screenshots provided, q2 storm dust results in progressively less value up to 10 q2 storm dust. At 11, the value starts increasing again and only by 13 is the value finally higher than full q1.

While I'm not sure if it will, I do hope this helps some.