When I try to switch profiles the drop down menu is behind the various setting options, and clicking the various profiles I wish to change to changes which setting screen I am on instead.

How do I fix?

In lieu of an actual fix, this might be being caused by another addon, such as one which allows you to move/resize the options frame, or "blizz bugs suck" or something similar to that.

I disabled the addon 'Skinner' and I was able to change it, not sure if that addon was the issue, but disabling it allowed me to change the profile and then re-enable it. Thanks for the help :D

I believe this should have been fixed by: 308b62f