Not sure if this is possible, but would it maybe be, to make an option to enable, that you can click on buffs / debuffs so it takes the unit into target? This would be really helpful to quickly select a NPC which has a Enrage you have to decurse. I have made the debuffs I can decurse really big so that would be handy.

This isn't possible due to API limitations; generally speaking you can't change the size of, move, or create new interactive frames while in combat.

You could use the frame padding options in /knp > frame sizes to increase the clickable area of nameplates, and stop them overlapping (if you have them set to stacking), but they'd need to be that size at all times.

Thank you very much for your answer! So I have to make the clickable area larger that's possible? Something like this:

https://i.imgur.com/X8tnci4.png

I want to be able to click on the X above the name frame, which would be an enrage buff for example. So making the clickable area larger by the amount of the buff height would do that?