I attempted to disenchant a world quest reward I didn't need. Used the molinari click shortcut (I use Shift-Alt-Left Click for this) and instead of DEing the quest reward, it disenchanted my offspec main hand weapon from heroic Vault! The original world quest drop was still there so I thought it just hadn't worked, did it again and now I have no offhand (got them back via item restore).

I used the regular in-game method to DE it (click disenchant, click item) and it worked as expected.