Downloaded Questie and it will not load. It's a fresh install. Using current WotLK Classic client.

You installed the wrong version of Questie. Follow this installation guide or simply grab the latest Questie version @selenn1986

The version you linked is the same one I downloaded and am currently trying to run. I downloaded it from Curseforge and it was updated 4 days ago (Version 7.0.1). Everyone in my household downloaded it from curseforge (3 different accounts/PCs) and it worked for everyone but me. On curseforge, it states to use version 7.0.0 for WotLK (just seeing this now). Downloaded it and tried it and it does work with the 7.0.0.

What does the AddOn section ingame and in the character selection say? And did you try to close the game, delete the Questie folder, then start up the game and check if Questie is still listed in your AddOn section. If it is, then you most likely have more than one WoW installation and are installing Questie to the wrong one.