Deactivated functions are displayed again after a reload, but the checkmark remains out, and players, targets, etc. no longer move. At the top right at the edge of the screen there is also a red box without function, but it cannot be removed

Player, target and target of target frames don't keep their positions after reload. Also got the red box in the corner.

Red box means you copied a old SUI 5 profile into SUI 6 and corrupted your database.

Reset your profile.

SUI should be spamming your chat on logon and when you mouse over the red box telling you.