More Immersive Wires 1.1.6
Modpack OceanBlock 2 1.5.0
Minecraft 1.21.1

I haven't extensively tested this, but the ME Dense Cable Connectors sometimes seem to break after logging out and reopening my single player world.

Some photos from my test world, it seems the North and East connections break, and after logging out and back in nothing else breaks.
I haven't tested the other types of connectors in the mod, but the Dense Relays seem to work perfectly fine. I'll update if anything changes, but it seems for now I can work around the North/East bug.

Also, breaking the AE2 Dense Cable and replacing doesn't fix it. The Dense Connector from More Immersive Wires must be broken and replaced to fix the issue until the world is closed and reopened.

EDIT: Updated a new photo, it seems it isn't just North/East. I haven't worked out why some connections are fine and others break but it seems to be repeatable on multiple world loads.