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Runes can be configured in any order you wish. You can also prioritize runes with shorter cooldowns in either order as well, and they will switch dynamically.
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People seem to think its the sword graphic only. There are many simple looks that DKiRunes is capable of to maximize UI real estate.
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Default layout for DKIRune Tracker and DKIDisease/Pestilence Tracker
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Simple Interface
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It's not a real disease, but Blood tanks need to be just as aware of this debuff as their diseases!
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Spinning animation highlights runes enabled by RE. Watch the demo video to do it justice.