Sometime in the last 10ish days, I noticed layer weirdness with (as it turned out) the Talking Head frame (unless "Hide" is checked). Any UI frame, base or addon, that is open is acting like the Talking Head is above it (but not visible because it's not "active") so no mouse input is registering. Opening up Edit Mode and closing it immediately solves the problem until the next login.

Can you find some steps that will always cause the problem after a /reload?

Sorry... Using v10.1-014 on Retail

Hey, saw this https://www.wowhead.com/news/new-micro-menu-visual-update-on-the-10-1-5-ptr-colorful-hd-icons-333394 just now. I see they integrated the lfg icon, so can get rid of that on minimap.

Oh I'm blind, what the hell is the point of minimap button if the micromenu icon does the same?

I don't see anything there about the LFG icon. They just gave the premade finder tool button some colour.

The minimap button is to remind you you're currently queued.

Blizzard could just make every micromenu button interactive and you'd use keyboard to actually open Group Finder for example.

Mine is not to question why Blizzard added buttons, only to let us move them!

I hope some day you will tip your toe into full on UI overhaul :)