I don't know if this is a usage issue or a bug but when I uncheck the Backpack frame when in edit mode, it disappears while I'm in edit mode but when I leave edit mode it comes back. I expected it to be hidden outside of edit mode as well.

Yes, thats the point of unchecking those. It behaves the same as the checkbuttons provided by Blizzard - it just shows/hides them during Edit Mode.

If you want to disable Edit Mode support for something completely, disable it through addon options:

If you want to hide the frame, select the frame and check Hide:

If you aren't offered the Hide option, let me know what you want to hide and I'll see if its possible to add support.

Thanks, totally missed that config frame, works beautifully. Thanks for making this!