My profile is generic across characters. I use Bartender for action bars/bag toggle and Plater nameplates. Skada is my current choice of DPS/HPS meters and I use a large amount of Weak Auras and BigWigs/LittleWigs to supplement my UI kit.
Disabled: Action Bars, Bags, Cooldown Text, Name Plates.
Plugins: ElvUI Floating Combat Text.