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You can add ("+" button) and delete ("-" button) set-ups to save them between sessions. These set-ups also remain when you e.g. select other set-ups, leave the raid, log out or exit WoW.
Changes you make are only saved when you press the "Save" b...
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Looks the same in a real raid, just with real names
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A blue background indicates that the members shown might not currently be in your raid, so you're editing a "virtual" set up.